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KMID : 0371420150880050276
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Annals of Surgical Treatment and Research
2015 Volume.88 No. 5 p.276 ~ p.280
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Noninvasive monitoring of mouse renal allograft rejection using micro-CT
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Hou Jiangang
Fujino Masayuki
Cai Songjie
Ding Qiang
Li Xiao-Kang
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Abstract
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Purpose: Acute renal graft rejection can only be definitively diagnosed by renal biopsy. However, biopsies carry a risk of renal transplant injury and loss. Micro-CT is widely used in preclinical studies of small animals. Here, we propose micro-CT could noninvasively monitor and evaluate renal location and function in a mouse kidney transplant model.
Methods: Orthotopic kidney transplantation was performed in a BALB/c -to- C57BL/6j or C57BL/6j-to- C57BL/6j mouse model. After optimizing imaging techniques, five mice were imaged with micro-CT and the findings were verified histologically.
Results: Micro-CT can monitor and evaluate renal location and function after orthotopic kidney transplantation. There were no mice deaths while renal transplants were failure.
Conclusion: We propose that graft micro-CT imaging is a new option that is noninvasive and specific, and can aid in early detection and follow-up of acute renal rejection. This method is potentially useful to improve posttransplant rejection monitoring.
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KEYWORD
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Kidney transplant, Micro-CT, Noninvasive monitoring
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